is a city in the U.S. state of Tennessee. It is the seat of Shelby County in the southwest part of the state and is situated along the Mississippi River. With a population of 633,104 at the 2020 U.S. census, Memphis is the second-most populous city in Tennessee, after Nashville. It is the fifth-most populous city in the Southeast, the nation's 28th-largest overall, and the largest city bordering the Mississippi River. The Memphis metropolitan area includes West Tennessee and the greater Mid-South region, which includes portions of neighboring Arkansas, Mississippi, and the Missouri Bootheel. One of the more historic and culturally significant cities of the southern U.S., Memphis has a wide variety of landscapes and distinct neighborhoods.